Article Date: 4/1/2007

The Latest in Lens Care Research from the AAO Annual Meeting
contact lens care

BY SUSAN J. GROMACKI, OD, MS, FAAO

The Latest in Lens Care Research from the AAO Annual Meeting

I attended the American Academy of Optometry’s annual meeting in Denver, and there’s much to report regarding lens care. The Academy’s Scientific Program showcases some of optometry’s best research. Following is a summary of the lens care presentations. Listed in brackets is the sponsor of the study, if applicable.

Lakkis and Boyd Opti-Free Replenish (Alcon) was effective vs. a broad range of P. aeruginosa clinical and laboratory isolates. [Alcon]

Dumbleton et al With all silicone hydrogel lenses, no cases of solution sensitivity staining were associated with Clear Care (CIBA Vision). [CIBA Vision]

Vermeltfoort et al Opti-Free Express (Alcon) is more effective than ReNu MultiPlus (Bausch & Lomb) in causing cell death of bacteria, with and without biofilm enclosure in a lens care system.

Schachet et al Opti-Free Replenish has clinical benefits with traditional and silicone hydrogel lenses vs. ReNu MultiPlus, ReNu MoistureLoc and Complete MoisturePlus (Advanced Medical Optics). [Alcon]

Groemminger et al In kill profiles of PHMB-containing products, ReNu MultiPlus performed best. [B&L]

McCanna et al ReNu MultiPlus, Complete Moisture Plus, and Aquify (CIBA) have minimal effect on human corneal epithelial cells in culture; Opti-Free Express has a greater effect on the tight junctions and cell membranes. [B&L]

Dalton et al Many solutions are more hypo-osmotic than tears. Lower values: Opti-Free Express; higher values: unneutralized Ultracare (AMO), AOSept (CIBA) and Clear Care. The pH of H2O2 solutions was less prior to neutralization; Opti-Free Express is highest. The viscosity of solutions at room temperature is similar (Complete is higher). Surface tension of AOSept and unneutralized UltraCare are similar to saline; Opti-Free Express and SoloCare (CIBA) are lowest.

Keir et al Clinical performance and subjective comfort with etafilcon lenses are similar for Opti-Free Express and ReNu MoistureLoc. Up to 10 percent of subjects have clinically significant corneal staining with an alexidine-based MPS vs. a polyquad-based MPS; staining is maximal 2 hours post-insertion. [Alcon]

Garofalo et al ReNu MultiPlus assayed over time in the lens case, with and without lenses, showed a decrease in PHMB content. Opti-Free Replenish did not show reduced Polyquad. A gradual increase in uptake was observed for both lenses (balafilcon A and etafilcon A) soaked in Complete MoisturePlus. [Alcon]

Baird et al Neither Opti-Free Replenish, Complete nor B&L Sensitive Eyes have large effects on visible light transmission or UV-A/B absorption of SCLs that are noticeable to the wearer.

Andrasko and Ryen After two hours of lens wear, PureVision with biguanide-preserved solutions had high percentages of staining area (ReNu MultiPlus, 73 percent; Complete MoisturePlus, 48 percent; Aquify, 21 percent). Staining area of 25 percent was observed for Acuvue 2 (Vistakon)/ReNu MoistureLoc. Night & Day (CIBA)/ReNu MultiPlus exhibited 24 percent staining area. Opti-Free Express and Opti-Free Replenish caused minimal staining (7 percent or less across all lenses). [Alcon]

Tilia et al Differences in rates of toxic staining with contact lens and solution combinations are evident. H2O2 solutions performed best irrespective of lens type. [CIBA]

Gromacki and Doud Greater volumes of solution were utilized for the manufacturers’ "no rub" instructions than for the traditional rub and rinse method. CLS

Dr. Gromacki is a Diplomate in Cornea and Contact Lenses in the American Academy of Optometry. She has a specialty contact lens and post-surgical co-management practice as part of a multi-subspecialty ophthalmology group in Ann Arbor, MI.


Contact Lens Spectrum, Issue: April 2007