Current Research in Corneal Reshaping
An in-depth review of some of the latest research
presented at the Global Orthokeratology Symposium.
By Craig W. Norman, FCLSA
recent 2005 Global Orthokeratology Symposium in Chicago was once again a success.
A well-known faculty presented numerous presentations on corneal reshaping topics
combined with an international Free Paper section and 30 scientific posters on this
While eyecare practitioners are becoming more
adept at fitting and managing ortho-k patients, we still have much to learn as this
field is evolving. The high attendance at the all-day Fundamentals of Orthokeratology
was a testament to practitioners' willingness to learn about this procedure.
Figure 1. Extent of astigmatism affects ortho-k
Figure 2. Axial (left) and tangential topography
Eef van der Worp, BSc Optom, reported on patient
selection in ortho-k with emphasis on choosing only patients whose spectacle prescriptions
and corneal topography are well-suited for this procedure. "While there are FDA
approvals for up to –6.00D of myopia, patients will generally have the most
predictable results up to –4.50D," stated Dr. van der Worp. "It's also important
to note not only the amount, but the location of any astigmatism. Today's designs
can correct only corneal astigmatism, primarily with-the-rule (WTR) astigmatism
where the axis is within 30 degrees of the horizontal meridian. Even then, only
a 50 percent reduction in the amount of astigmatism can occur, therefore choose
only patients who have a maximum of –1.50D of WTR astigmatism," he said. Also,
it's helpful to note if the corneal astigmatism is apical only or extends from limbus
to limbus (Figure 1). "Patients who have limbus-to-limbus astigmatism are difficult
to fit due to lens rocking and the tendency for the lens to position high on the
cornea," said Dr. van der Worp.
Randy Kojima from Vancouver, BC, presented
Pre-fitting Corneal Topography for Corneal Reshaping, pointing out that a real key
to successful ortho-k fitting is the acquisition of accurate corneal maps at pre-fitting
and during progress checks.
"The initial information capture is
the most critical," said Kojima. "Multiple image captures are much more useful than
taking just one single corneal measurement." He continued, "Then, to ensure accuracy,
I review the maps simultaneously to look for symmetry between captures along with
any obvious error. If I'm concerned about the quality and reproducibility of the
images, I take additional maps as necessary."
Kojima also explained how to use different
maps. "The axial map is best for defining astigmatism and determining the apical
radius. Conversely, a tangential (instantaneous/true) map is best for determining
curvature at a specific point," he said (Figure 2).
real key, though, is the use of difference (or subtractive) maps, which plot the
difference between two captures such as a baseline (pre-fit) measurement
and a post-fit visit. This demonstrates specific changes in radius and prescription
during the fitting process. Subtractive Maps are also quite useful for evaluating
the position and size of the treatment zone, the lens position (because the lens
usually isn't worn into the office) and any surface aberrations that have occurred
secondary to overnight ortho-k wear.
Research from the General Sessions
Myopia A real highlight of the
symposium was a discussion of myopia and a review of investigations and studies
on contact lens-induced myopia control.
Brien A. Holden, B App Sc, PhD, from Sydney,
Australia led off this discussion with a review of myopia across the world. "Myopia
affects 1.6 billion people globally and is a serious public health issue," stated
Dr. Holden, quoting studies demonstrating that higher myopic patients (above –6.00D)
have an increased risk of retinal detachment, cataracts and glaucoma. "Uncorrected
myopia decreases quality of life, increases economic cost and reduces learning opportunities
for children," he said.
"While myopia is viewed as simply a
correctable error in the Unites States, there are countries in Southeast Asia such
as Taiwan and Hong Kong where up to 80 percent of the overall population is myopic,"
said Dr. Holden. "In fact, the World Health Organization has identified uncorrected
refractive errors as one of the five priority areas for The Global Initiative to
Eliminate Avoidable Blindness by the Year 2020."
Earl L. Smith III, OD, PhD, from the
University of Houston, in his presentation on the Mechanisms of Myopia, described
many of the longstanding theories regarding the etiology of myopia, based on both
genetic and environmental factors. Quoting a 1977 study by Wiesel & Raviola,
he discussed form deprivation myopia (FDM) where depriving the eye of form vision
promotes axial elongation and myopia (chronic image degradation can cause myopia).
Of importance, the ocular changes in FDM are similar to those associated with juvenile-onset
myopia. Therefore, the potential for a clear retinal image is essential for normal
Dr. Smith believes that peripheral
vision can influence foveal refractive development. "Peripheral form deprivation
can produce axial myopia at the fovea," he stated, "and the peripheral retina by
itself can regulate emmetropization." He also discussed how a functioning fovea
is not essential for emmetropizing responses.
"As a consequence of eye shape and/or
aspheric optical surfaces, 'corrected' myopic eyes often experience significant
hyperopic defocus across the visual field. Under-correction may not be an effective
strategy for slowing myopic progression because small degrees of under-correction
aren't likely to eliminate peripheral hyperopic errors," Dr. Smith stated. "By increasing
the effective curvature of field it would be possible to correct central errors
and either correct peripheral errors or induced peripheral myopic defocus." This
may explain why some of the earlier efforts in studying myopia control with GP lenses
demonstrated results that were less positive than anecdotal reports have suggested
through the years. Such studies "focused" images clearly on the fovea rather that
utilizing a "defocus" mechanism.
Control with GP Lenses Jeffrey J. Walline, OD, PhD, presented the CLAMP
Study results. (You can see these results in detail by turning to Dr. Walline's
article "GP Contact Lenses and Myopia Control: Where Are We Now?" on p. 52.) One
of the more interesting findings of his work was that 80 percent of the myopic children
enrolled in this study initially adapted to GP wear with 70 percent of successful
adapters becoming "lifetime" wearers. Dr. Walline concluded that GPs slowed myopia
progression significantly, but the treatment effect is likely not permanent with
Pauline Cho, BOptom, PhD, from
Hong Kong Polytechnic University discussed Myopia Control With Orthokeratology.
She set out to determine if ortho-k is effective for myopia reduction and control
through a two-year study that monitored axial length (AL) and vitreous chamber depth
(VCD) changes in children undergoing ortho-k treatment. She then compared this data
to the rates of change in AL & VCD for 35 children wearing single-vision spectacles
from an earlier study.
Figure 3. After 24 months of overnight ortho-k
wear, children's AL and VCD increased only about half as much as that of the
The subjects were children aged 7 to
12 years who had a spherical refractive error of –0.25D to –4.50D and
astigmatism less than –2.00D. Among the many data collected were vision (logMAR
chart), refraction, corneal topography/thickness, AL and VCD.
Of the initial 43 subjects, 35 (16
male, 19 female) completed the study. Researchers evaluated eye elongation over
the 24-month monitoring period. The mean change in AL was 0.14mm (about 0.39D) for
the ortho-k group and 0.27mm (about 0.75D) for the control subjects (Figure 3).
in the AL and VCD changes was quite large on average, ortho-k lens wear significantly
slowed eye elongation, but some children still showed a large increase.
In conclusion, ortho-k was effective
for myopic reduction, and the mean eye elongation in ortho-k children was about
half that of spectacle-wearing children. While this is just one study and has a
small study sample, it shows that ortho-k may prove an option for slowing myopia
progression in children.
Optics of Orthokeratology
If orthokeratology may indeed control myopia progression, what optics of orthokeratology
will facilitate this?
Jennifer Choo, OD, from Sydney, Australia
presented a paper on this topic. Her interest is to determine the ideal shape of
the cornea after ortho-k and to understand the optical limits to correction with
varying pupil sizes and refractive errors.
Using software, an optical model of
the eye was created with various pupil sizes (3.0mm to 6.5mm), a series of refractive
errors (up to –8.00D), epithelium isolated as a variable in thickness and
ray tracing optimized for defocus and aberrations.
"Optical modeling provides a useful
tool for understanding optical changes and may be useful to help design lenses to
optimize patient vision," said Dr. Choo. "There is an ideal shape of the cornea
after orthokeratology. To correct vision, the shape will aim to minimize optical
defocus and aberrations. In particular, to decrease myopia progression, it will
likely need to incorporate aberration control."
Ortho-k vs. Soft Lens Wear
Michael J. Lipson, OD, from the University of Michigan presented Overnight Corneal
Reshaping vs. Soft Disposable Contact Lenses: Vision-Related Quality of Life Differences
From a Randomized Clinical Trial. This study evaluated patients' visual acuity,
symptoms and perceptions of vision-related quality of life in a randomized crossover
clinical trial of overnight corneal reshaping (OCR) using Paragon CRT lenses and
daily wear disposable soft lenses (SCL).
He evaluated the vision-related quality
of life with the NEI RQL-42, which consists of 42 multiple choice questions that
rate many attributes such as overall clarity, near and far vision, diurnal fluctuations,
expectations and activity limitations, etc.
Researchers randomly assigned qualified
subjects to wear one mode for eight weeks and complete the RQL-42 at the end of
that time. After a washout period, each subject wore the alternate mode for eight
weeks, completed the RQL-42 then chose which mode they preferred. Of 81 subjects
who enrolled, 65 subjects completed both phases.
Figure 4. Most lower myopes and some
higher myopes preferred ortho-k correction to soft lens correction.
Among the perception of vision-related
quality of life were some statistically significant differences. Activity limitations
were better or less limited with OCR, while glare was less bothersome with SCL.
Patients had less dependence on correction and fewer ocular symptoms with OCR. After
completing the study, 67.7 percent of the overall study population preferred to
continue with OCR (Figure 4) even though measured VA was better with SCL. Low myopes
prefer OCR over SCL although glare is more of an issue with OCR. While measured
acuity was better with SCL, subjective acuity wasn't significantly different between
the two modes.
When asked what you can tell your patients
about this study, Dr. Lipson responded, "For patients who have higher amounts of
myopia, such as –4.25D, SCL vision is slightly better and glare will be less
of a problem. Conversely, an SCL patient will be more prone to lens awareness, itching
"For patients who have up to –2.50D
correction and who tried CRT and SCL, 85 percent preferred CRT. Vision with CRT will
be comparable, and although patients will find glare slightly more noticeable, they'll
feel less activity-limited, they'll have less problem with dry eyes, itching or
lens awareness during the day, plus they'll feel less dependent on their correction."
Craig Norman is director of the Contact Lens
Section at the South Bend Clinic in South Bend, Indiana. He is a fellow of the
Contact Lens Society of America and is an advisor to the GP Lens Institute.
Contact Lens Spectrum, Issue: October 2005