Contact Lens Spectrum


December 2011

Document #193



(p. 18) Point/Counterpoint: Silicone Hydrogels: Were They Really Worth It?

(Point) Silicone Hydrogels: A Vast Improvement

By David A. Berntsen, OD, PhD, FAAO

1. Carney FP, Nash WL et al. The adsorption of major tear film lipds in itro to various silicone hydrogels over time. Invest Ophthalmol Vis Sci. 2008;49:120-124.

2. Cover M, Sweeney DF. Hypoxic effects on the anterior eye of high-Dk soft contact lens wearers are negligible. Optom Vis Sci. 2001;78:95-99.

3. Dumbleton K. Noninflammatory silicone hydrogel contact elns complications. Eye Contact Lens. 2003;29(1Suppl):S186-189; discussion S190-191, S192-194.

4. Dumbleton K, Keir N et al. Objective and subjective responses in patients refitted to daily-wear silicone hydrogel contact lenses. Optom Vis Sci. 2006;83:758-768.

5. Dumbleton KA, Chalmers RL. Vascular response to extended wear of hydrogel lenses with high and low oxygen permeability. Optom Vis Sci. 2001;78:147-151.

6. Dumbleton A, Woods CA, et al. Comfort and adaptation to silicone hydrogen lenses for daily wear. Eye Contact Lens. 2008;34:215-223.

7. Fonn D, MacDonald KE, et al. The ocular response to extended wear of a high-DK silicone hydrogel contact lens. Clin Exp Optom. 2002;85:176-182.

8. Holden BA, Stephenson A, et al. Superior epithelial arcuate lesions with soft contact lens wear. Optom Vis Sci. 2001;78:9-12.

9. Jalbert I, Stretton S. Changes in myopia with low-Dk hydrogel and high-Dk silicone hydrogel extended wear. Optom Vis Sci. 2004;81:591-596.

10. Maldonado-Codina C, Morgan PB, et al. Short-term physiologic response in neophyte subjects fitted with hydrogel and silicone hydrogel contact lenses. Optom Vis Sci. 2004;81:911-921.

11. Nichols JJ. Deposition rates and lens care influence on galyfilcon A silicone hydrogel lenses. Optom Vis Sci. 2006;83:751-757.

12. Stapleton F, Keay L, et al. The incidence of contact lens-related microbial keratitis in Australia. Ophthalmology. 2008;115:1655-1662.

13, Szczotka-Flynn L, Lass JH, et al. Risk factors for corneal infiltrative events during continuous wear of silicone hydrogel contact lenses. Invest Ophthalmol Vis Sci. 2010;51:5421-5430.

14. Young G, Riley CM, et al. Hydrogel lens comfort in challenging environments and the effects of refitting with silicone hydrogel lenses. Optom Vis Sci. 2007;84:302-308.

15. Zhao Z, Carnt NA. Care regimen and lens material influence on silicone hydrogel contact lens deposition. Optom Vis Sci. 2009;86:251-259.

16. Zhu H, Bandara MB, et al. Importance of rub and rinse in use of multipurpose contact lens solution. Optom Vis Sci. 2011;88:967-972.


(p. 18) (Counterpoint) A Fascinating But Disappointing Experiment

By Graeme Young, Mphil, PhD, FCOptom, DCLP, FAAO

1. Szczotka-Flynn L, Diaz M. Risk of corneal inflammatory events with silicone hydrogel and low Dk hydrogel extended contact lens wear: a meta-analysis. Optom Vis Sci. 2007;84:247-256.

2. Wagner H, Chalmers RL, Mitchell GL, et al. Risk factors for interruption to soft contact lens wear in children and young adults. Optom Vis Sci. 2011;88:973-980.

3. Tan J, Keay L, Jalbert I, Naduvilath TJ, Sweeney DF, Holden BA. Mucin balls with wear of conventional and silicone hydrogel contact lenses. Optom Vis Sci. 2003; 80:291-297.

4. Jalbert I, Stretton S, Naduvilath T, Holden B, Keay L, Sweeney D. Changes in myopia with low-Dk hydrogel and high-Dk silicone hydrogel extended wear. Optom Vis Sci. 2004;81:591-596.

5. Dillehay SM. Does the level of available oxygen impact comfort in contact lens wear? A review of the literature. ECL. 2007;33:148-155.



(p. 24) Dry Eye Dx and Tx: Combating Sick Building Syndrome

By Katherine M. Mastrota, MS, OD, FAAO

1. Indoor Air Facts No. 4 (revised) Sick Building Syndrome.

2. Kim KJ, Jeong M, Lee DW, et al. Variation in formaldehyde removal efficiency among indoor plant species. HortScience. 2010;45:1489-1495.

3. Prescod AW. (1992). More indoor plants as air purifiers. Pappus, 11:4.

4. Wolverton BC. (1990). Interior Landscape Plants and Their Role in Improving Indoor Air Quality. Wolverton Environmental Services Inc., Picayune, Mississippi.



(p. 26) Corneal Cross-linking and Orthokeratology

By Sami El Hage, OD, PhD, DSc, FAAO, & Theo Seiler, MD, PhD

1. Calossi A, Romano F, Ferraioli G, Romano V. Orthokeratology and riboflavin-UVA corneal collagen cross-linking in keratoconus. Paper presented at: 26th Congress of the European Society of Cataract and Refractive Surgeons; Sept. 13-17, 2008; Berlin.

2. El Hage SG, Leach NE, Colliac JP, et al. Controlled kerato-reformation (CKR): an alternative to refractive surgery. Paper presented at: Annual Meeting of American Academy of Optometry; 1995; New Orleans, LA.

3. El Hage SG, Leach NE, Colliac JP, et al. An interactive software for CKR nomograms. Contact Lens Spectrum. 1997; 54.

4. El Hage S, Leach NE, Milller W, et al. Empirical advanced orthokeratology through corneal topography: the University of Houston clinical study. Eye & Contact Lens. 2007;33: 224-235.

5. El Hage SG, Leach NE, Shahin R. Controlled kerato-reformation: an alternative to refractive surgery. Practical Optometry. 1999;10:230-236.

6. Jurkus J, Gunderson G, Zoltoski R. In vivo orthokeratological corneal changes observed with optical coherence tomography. Poster presented at: Global Specialty Lens Symposium; Jan. 15-18, 2009; Las Vegas, NV.

7. Mazzotta C, Balestrazzi A, Traversi C, et al. Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans [Clinical Science]. Cornea. 2007;26:390-397.

8. Schnitzler E, Spörl E, Seiler T. Bestrahlung der hornhaut mit UV-licht und riboflavingabe als neuer behandlungsversuch bei einschmelzenden hornhautprozessen. Klin Monatsbl Augenheilkd. 2000;217:190-193.

9. Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res. 1998;66:97-103.

10. Spoerl E, Mrochen M, Sliney D, et al. Safety of UVA-riboflavin cross-linking of the cornea [Review]. Cornea. 2007;26:385-389.

11. Stillitano P, Schor C, Lipener A., et al. Wavefront aberrations after orthokeratology. J Refr Surg. 2007;23.

12. Wollensack G, Sporl E, Seiler T. Treatment of keratoconus by collagen cross-linking. Der Ophthalmologue. 2003;100:44-49.



(p. 30) These Aren’t Your Father’s Contact Lenses

By Pete S. Kollbaum, OD, PhD, FAAO

1. Aller TA, Wildsoet C. Bifocal soft contact lenses as a possible myopia control treatment: a case report involving identical twins. Clin Exp Optom. 2008;91:394-399.

2. Cho P, Cheung SW, Edwards M. The longitudinal orthokeratology research in children (LORIC) in Hong Kong: a pilot study on refractive changes and myopic control. Curr Eye Res. 2005;30:71-80.

3. Ciolino JB, Hoare TR, Iwata NG, et al. A drug-eluting contact lens. Invest Ophthalmol Vis Sci. 2009;50:3346-3352.

4.Gulsen D, Chauhan A. Ophthalmic drug delivery through contact lenses. Invest Ophthalmol Vis Sci. 2004;45:2342-2347.

5. Holden B, de la Jara PL. Contact lenses: optimal vision--sub-optimal carrier? Optom Vis Sci. 2007;84:365-367.

6. Holden BA, Fricke TR, Ho SM, et al. Global vision impairment due to uncorrected presbyopia. Arch Ophthalmol. 2008;126:1731-1739.

7. Karlgard CC, Jones LW, Moresoli C. Ciprofloxacin interaction with silicon-based and conventional hydrogel contact lenses. Eye Contact Lens. 2003a;29:83-89.

8. Karlgard CC, Wong NS, Jones LW, Moresoli C. In vitro uptake and release studies of ocular pharmaceutical agents by silicon-containing and p-HEMA hydrogel contact lens materials. Int J Pharm. 2003b;257:141-151.

9. Kollbaum P, Bradley A, Thibos LN. Ghosting and Presbyopic Correction. Presented at: American Academy of Optometry Annual Meeting; 2011; Boston, MA.

10. Morgan PB, Woods CA, Nichols JJ, consortium TICLP. International Contact Lens Prescribing in 2010. Contact Lens Spectrum. 2011.

11. Mutti DO, Sholtz RI, Friedman NE, Zadnik K. Peripheral refraction and ocular shape in children. Invest Ophthalmol Vis Sci. 2000;41:1022-1030.

12. Peng CC, Chauhan A. Extended cyclosporine delivery by silicone-hydrogel contact lenses. J Control Release. 2011.

13. Rah M.J., Jackson J.M., Jones L.A., Marsden H.J., Bailey M.D., Barr J.T. (2002) Overnight orthokeratology: preliminary results of the Lenses and Overnight Orthokeratology (LOOK) study. Optom Vis Sci 79:598-605.

14. Richdale K, Mitchell GL, Zadnik K. Comparison of multifocal and monovision soft contact lens corrections in patients with low-astigmatic presbyopia. Optom Vis Sci. 2006;83:266-273.

15. Rose KA, Morgan IG, Smith W, Burlutsky G, Mitchell P, Saw SM. Myopia, lifestyle, and schooling in students of Chinese ethnicity in Singapore and Sydney. Arch Ophthalmol. 2008;126:527-530.

16. Sahoo SK, Dilnawaz F, Krishnakumar S. Nanotechnology in ocular drug delivery. Drug Discov Today. 2008;13:144-151.

17. Smith EL 3rd, Ramamirtham R, Qiao-Grider Y, et al. Effects of foveal ablation on emmetropization and form-deprivation myopia. Invest Ophthalmol Vis Sci. 2007;48:3914-3922.

18. Walline JJ. The Effect of Soft Bifocal Contact Lenses on Myopia Progression in Children. Presented at: American Academy of Optometry; 2011; Boston, MA.

19. Walline JJ, Jones LA, Sinnott LT. Corneal reshaping and myopia progression. Br J Ophthalmol. 2009;93:1181-1185.

20. Walline JJ, Jones LA, Mutti DO, Zadnik K. A randomized trial of the effects of rigid contact lenses on myopia progression. Arch Ophthalmol. 2004;122:1760-1766.

21. Zheleznyak L, Sabesan R, Oh JS, Yoon G. Modified Monovision to Improve Binocular Through-Focus Visual Performance. Presented at the Association for Research in Vision and Ophthalmology Annual Meeting; 2011; Fort Lauderdale, FL.



(p. 36) A New-generation Multipurpose Disinfecting Solution

By J. James Thimons, OD, FAAO

1. Stone R. The importance of compliance: Focusing on the key steps.  Poster presented at: British Contact Lens Association Meeting; May 2007; Manchester, UK.

2. Poll: Some at risk by contact lens hygiene.” United Press International, Oct. 20, 2010.

3. Stapleton F, Keay L, Edwards K, et al. The incidence of contact lens-related microbial keratitis in Australia. Ophthalmology. 2008;115:1655-1662.

4. Schein OD, McNally JJ, Katz J, et al; The incidence of microbial keratitis among wearers of a 30-day silicone hydrogel extended-wear contact lens. Ophthalmology. 2005;112:2172-2179.

5. Zhu H, Bandara R, Masoudi S, et al. Evaluation of antimicrobial efficacy of multipurpose solutions against clinical microbial isolates. Presented at: British Contact Lens Association Meeting; May 25, 2010; Birmingham, UK.

6. Powell H, Hoong L, Kilvington S, et al. Evaporation effects on the efficacy of contact lens multipurpose solutions. Poster presented at: British Contact Lens Association Meeting; May 2010; Birmingham, UK.

7. Morgan PV, Proniuk S, Blanchard J, Noecker RJ. Effect of temperature and light on the stability of latanoprost and its clinical relevance. J Glaucoma. 2001;10:401-405.



(p. 40) Communicating the Importance of Lens Care

By Bruce W. Anderson, OD, FAAO

1. American Academy of Ophthalmology. Preferred Practice Pattern: Dry Eye Syndrome. Available at: 2008. Accessed November 2, 2010.

2. American Optometric Association. Acanthamoeba. Available at: Accessed November 4, 2010.

3. American Optometric Association. Computer Vision Syndrome. Available at: Accessed November 4, 2010.

4. American Optometric Association. Dry Eye. Available at: Accessed November 3, 2010.

5. Chalmers RL. Begley CG. Use your ears to identify lens related dryness. Contact Lens Spectrum. August 2005. Available at: Accessed December 21, 2010.

6. Guillon M, Maissa C. Contact lens wear affects tear film evaporation. Eye Contact Lens. 2008;34:326-330.

7. International Dry Eye WorkShop. Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007c;5:108-152.

8. International Dry Eye WorkShop. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007b;5:75-92.

9. International Dry Eye WorkShop. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007a;5:93-107.

10. Lakkis C, Lakkalo S. Antibacterial lens case efficacy during silicone hydrogel daily wear. Cont Lens Anterior Eye. 2006;29:205.

11. Merchea M, Burke SE, Fridman KM, Scheuer CA, Barniak VL, Reindel W. Clinical performance of a novel multi-purpose solution (BioTrue) formulated with physical properties to match healthy tears. Poster presented at: 2010 Contact Lens Association of Ophthalmologists Education & Research Foundation Scientific Symposium; September 23-25, 2010; Las Vegas, NV, USA.

12. Nichols JJ, Ziegler C, Mitchell GL, et al. Self-reported dry eye disease across refractive modalities. Invest Ophthalmol Vis Sci. 2005;46:1911-1914.

13. Reference available at: Accessed November 5, 2010.

14. Schorner S. Some facts about SiHy lenses. Review of Optometry. July 15, 2010. Available at: Accessed November 5, 2010.

15. Vincent S, Lakkis C. Predictive factors of contact lens case contamination. Optom Vis Sci. 2007;84:E-abstract 075159.



(p. 48) Treatment Plan: Corneal Mycotic Infections

By William L. Miller, OD, PhD, FAAO

1. Ritterband DC, Seedor JA, Shah MK, et al Fungal keratitis at the new York Eye and Ear Infirmary. Cornea. 2006;25:264-267.

2. Tuli SS. Fungal keratitis. Clin Ophthalmol. 2011;5:275-279.

3. Siatiri H, Daneshgar F, Siatiri N, Khodabande A The effects of intrastromal voriconazole injection and topical voriconazole in the treatment of recalcitrant fusarium keratitis. Cornea. 2011;30:872-875.



(p. 50) Reader and Industry Forum: Medication Delivery Via Contact Lens

By Agustin Gonzalez, OD

1. Sedlacek J. Possibilities of application of ophthalmic drugs with the aid of gel-contact lenses. Cesk Ophtalmol. 1965;21:509-512.

2. Gulsen D, Chauhan A. Ophthalmic drug delivery through contact lenses. Invest Ophthalmol Vis Sci. 2004;45:2342-2347.

3. Busin V, Spitznas M. Sustain gentanicin release by pre-soaked medicated bandage contact lenses Ophthalmology (Rochester). 1988;95:796-798.

4. Hull DS, Edelhauser HF, Hyndiuk V. Ocular penetration of predisolone and the hydrophilic contact lens. Arch Ophthalmol. 1974;92:413-416.

5. Podoos SM, Becker B, Asseff C, Harstein J. Pilocarpine therapy with soft contact lens. Am J Ophthalmol. 1972;73:336-341.

6. Jain MR. Drug delivery through soft contact lenses. Br J Ophthalmol. 1988;72:150-154.

7. Chow EPY, Yang YY. Polymer having interconnected pores for drug delivery and method, 2007; US Patent No. 0154522 A1.

8. Alvarez-Lorenzo C, Concheiro-Nine A. Drug-loaded soft contact lenses. Arch Soc Esp Oftalmol. 2008;83:73-4.  

9. Sato T, Uchida R, Tanigawa H, Uno V, Murakami A. Application of polymer gels containing side-chain phosphate groups to drug-delivery contact lenses. J Appl Polym Sci. 2005;98:731-735.

10. Alvarez-Lorenzo C, Yañez F, Barreiro-Iglesias R, Concheiro A. Imprinted soft contact lenses as norfloxacin delivery systems. J Control Release. 2006;113:236-244.

11. Hiratani H, Fujiwara A, Tamiya Y, Mizutani Y, Alvarez-Lorenzo C. Ocular release of timolol from molecularly imprinted soft contact lenses. Biomater. 2005;26:1293-1298.

12. Gulsen D, Chauhan A. 2009 Ophthalmic drug delivery system US Pat. No.7638137.

13. Creech JL, Chauhan A, Radke CJ. Dispersive mixing in the posterior tear film under a soft contact lens. IEC Res. 2001; 40:3015-3026.

14. McNamara NA, Polse KA, Brand RD, Graham AD, Chan JS, McKenney CD. Tear mixing under a soft contact lens: Effects of lens diameter. Am J Ophthalmol. 1999;127:659-665.

15. Ehlers WH. Silicone contact lens materials not effective for drug delivery. Eye Contact Lens. 2008;34:266-271.

16. Ciolino JB, Hoare TR, Kohane DS. Contact lens drug delivery device, US patent 0329637 A1:2010.

17. Ciolino JB, Hoare TR, Iwata NG. A drug-eluting contact lens. Invest Ophthalmol Vis Sci. 2009;50:3346-3352.

18. Jha G, Kumar A. Drug delivery through soft contact lenses: An introduction. Chron Young Sci. 2011;2:3-6.



(p. 52) Reader and Industry Forum: Aspheric Optics for Aberration

Control vs. Conventional Optics

By Gerard Cairns, PhD, MCOptom, FAAO

1. Mack CJ, Merchea M, Thomas H. A global survey reveals vision needs of highest importance amongst a vision-corrected population. American Academy of Optometry. San Francisco, CA, 2010.

2. Cox I, Kingston A, Vogt AKS. Wavefront aberrations of the human eye - a large population study. BCLA. Manchester, UK2011.

3. Applegate RA. Glenn Fry award lecture 2002: wavefront sensing, ideal corrections, and visual performance. Optom Vis Sci. Mar 2004;81:167-177.

4. Cairns G. Enhancing contact lens design for complete performance. Optician. 2007(February):14-16.



End Document #193