Contact Lens Spectrum


January 2018

Document #266

(p. 12) Research Review – Do Contact Lenses Affect the Meibomian Glands?
By Maria Markoulli, PhD, MOptom, GradCertOcTher

  1. Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS II Epidemiology Report. Ocul Surf. 2017 Jul;15:334-365.
  2. Pritchard N, Fonn D, Brazeau D. Discontinuation of contact lens wear: a survey. Int Contact Lens Clin. 1999 Nov;26:157-162.
  3. Alghamdi WM, Markoulli M, Holden BA, Papas EB. Impact of duration of contact lens wear on the structure and function of the meibomian glands. Ophthalmic Physiol Opt. 2016 Mar;36:120-131.
  4. Markoulli M, Papas E, Cole N, Holden B. Effect of contact lens wear on the diurnal profile of matrix metalloproteinase 9 in tears. Optom Vis Sci. 2013 May;90:419-429.
  5. Henriquez AS, Korb DR. Meibomian glands and contact lens wear. Br J Ophthalmol. 1981 Feb;65:108-111.
  6. Ong BL, Larke JR. Meibomian gland dysfunction: some clinical, biochemical and physical observations. Ophthalmic Physiol Opt. 1990 Apr;10:144-148.
  7. Machalińska A, Zakrzewska A, Adamek B, et al. Comparison of morphological and functional Meibomian gland characteristics between daily contact lens wearers and nonwearers. Cornea. 2015 Sep;34:1098-1104.
  8. Arita R, Itoh K, Inoue K, Kuchiba A, Yamaguchi T, Amano S. Contact lens wear is associated with decrease of meibomian glands. Ophthalmology. 2009 Mar;116:379-384.
  9. Arita R, Fukuoka S, Morishige N. Meibomian Gland Dysfunction and Contact Lens Discomfort. Eye Contact Lens. 2017 Jan;43:17-22.
  10. Siddireddy JS, Vijay AK, Tan J, Willcox M.The eyelids and tear film in contact lens discomfort. Cont Lens Anterior Eye. 2017 Oct 17. [Epub ahead of print]
  11. Villani E, Ceresara G, Beretta S, Magnani F, Viola F, Ratiglia R. In vivo confocal microscopy of meibomian glands in contact lens wearers. Invest Ophthalmol Vis Sci. 2011 Jul;52:5215-5219.
  12. Na KS, Yoo YS, Hwang HS, Mok JW, Kim HS, Joo CK. The influence of overnight orthokeratology on ocular surface and meibomian glands in children and adolescents. Eye Contact Lens. 2016 Jan;42:68-73.
  13. Hom MM, Martinson JR, Knapp LL, Paugh JR. Prevalence of Meibomian gland dysfunction. Optom Vis Sci. 1990 Sep;67:710-712.
  14. Marren SE. Contact-Lens Wear, Use of Eye Cosmetics, and Meibomian Gland Dysfunction. Optom Vis Sci. 1994 Jan;71:60-62.
  15. Ong BL. Relation between contact lens wear and meibomian gland dysfunction. Optom Vis Sci. 1996 Mar;73:208-210.
  16. Nichols JJ, Sinnott LT. Tear film, contact lens, and patient-related factors associated with contact lens-related dry eye. Invest Ophthalmol Vis Sci. 2006 Apr;47:1319-1328.
  17. Pucker AD, Jones-Jordan LA, Li W, et al. Associations with meibomian gland atrophy in daily contact lens wearers. Optom Vis Sci. 2015 Sep;92:e206-e213.
  18. Korb DR, Henriquez AS. Meibomian gland dysfunction and contact lens intolerance. J Am Optom Assoc. 1980 Mar;51:243-251.
  19. Lambiase A, Sullivan BD, Schmidt TA, et al. A Two-Week, Randomized, Double-masked Study to Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye Disease. Ocul Surf. 2017 Jan;15:77-87
  20. Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea. 2012 May;31:472-478.

(p. 14) Prescribing for Presbyopia – Soft Toric Multifocals: Fix Astigmatic Correction First
By Thomas G. Quinn, OD, MS

  1. Richdale K, Berntsen DA, Mack CJ, Merchea MM, Barr JT. Visual acuity with spherical and toric soft contact lenses in low- to moderate-astigmatic eyes Optom Vis Sci. 2007 Oct;84:969-975.
  2. Madrid-Costa D, Tomás E, Ferrer-Biasco T, Garcia-Lázaro S, Montés-Micó R. Visual performance of a multifocal toric soft contact lens. Optom Vis Sci. 2012 Nov;89:1627-1635.
  3. Fernandes PR, Neves HI, Lopes-Ferreira DP, Jorge JM, González-Meijome JM. Adaptation to multifocal and monovision contact lens correction. Optom Vis Sci. 2013 Mar;90:228-235.

(p. 15) GP Insights – Keratoconus Management: A Preliminary Guide
By Edward S. Bennett, OD, MSEd, & Ariel Cerenzie, OD

  1. Bennett ES. GP annual report 2017. Contact Lens Spectrum. 2017 October;32:22-25, 29-31.
  2. Hauswirth SG. Today’s Cross-Linking: It’s Not Your Father’s Oldsmobile. Contact lens Spectrum. 2017 Sep;32:28-30,32,34.
  3. McMahon T. CLEK Topography Assessment Group. Presented at the Global Keratoconus Congress, Las Vegas, Jan. 2008.

(p. 18) Dry Eye Dx and Tx – Acupuncture for Dry Eye: Not So Pointless
By William Townsend, OD

  1. Belgrade M, Huntoon E. A primer on acupuncture. Minn Med. 2009 May;92:40-3.
  2. Liu Q, Liu J, Ren C, et al. Proteomic analysis of tears following acupuncture treatment for menopausal dry eye disease by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry. Int J Nanomedicine. 2017 Feb 28;12:1663-1671.
  3. Yang L, Yang Z, Yu H, Song H. Acupuncture therapy is more effective than artificial tears for dry eye syndrome: evidence based on a meta-analysis. Evid Based Complement Alternat Med. 2015;2015:143858.
  4. Mingfu L, Xiaotong D, Xiaojing S, Jin J, Jinling Z, Ying H. Study on the dynamic compound structure composed of mast cells, blood vessels, and nerves in rat acupoint. Evid Based Complement Alternat Med. 2013;2013:160651.
  5. Yin N, Yang H, Yao W, Ding G. A mathematical model of histamine-mediated neural activation during acupuncture. Biomech Model Mechanobiol. 2017 Oct;16:1659-1668
  6. Kim DH, Ryu Y, Hahm DH. Acupuncture points can be identified as cutaneous neurogenic inflammatory spots. Sci Rep. 2017 Nov 9;7:15214.

(p. 19) Contact Lens Care & Compliance – Lens-Associated Corneal Neovascularization
By Andrew D. Pucker, OD, PhD

  1. Sweeney DF. Have silicone hydrogel lenses eliminated hypoxia? Eye Contact Lens. 2013 Jan;39:53-60.
  2. Wong AL, Weissman BA, Mondino BJ. Bilateral corneal neovascularization and opacification associated with unmonitored contact lens wear. Am J Ophthalmol. 2003 Nov;136:957-958.
  3. Abdelfattah NS, Amgad M, Zayed AA, et al. Clinical correlates of common corneal neovascular diseases: a literature review. Int J Ophthalmol. 2015 Feb;8:182-193.
  4. Liesegang TJ. Physiologic changes of the cornea with contact lens wear. CLAO J. 2002 Jan;28:12-27.
  5. Lee DS, Kim MK, Wee WR. Biometric risk factors for corneal neovascularization associated with hydrogel soft contact lens wear in Korean myopic patients. Korean J Ophthalmol. 2014 Aug;28:292-297.
  6. Nomura K, Nakao M, Matsubara K. Subjective symptom of eye dryness and lifestyle factors with corneal neovascularization in contact lens wearers. Eye Contact Lens. 2004 Apr;30:95-98.

(p. 45) Orthokeratology Today – Extensive Research Supports Ortho-k Clinical Success
By Michael J. Lipson, OD

  1. Paragon Vision Sciences. FDA Approval Study Data for paflufocon B and paflufocon D rigid gas permeable contact lenses. Available at . Accessed on Oct. 23, 2017.
  2. Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, Gutiérrez-Ortega R. Orthokeratology vs. spectacles: adverse events and discontinuations. Optom Vis Sci. 2012 Aug;89:1133-1139.
  3. Lipson MJ. Long-term Clinical Outcomes for Overnight Corneal Reshaping In Children and Adults. Eye Contact Lens. 2008 Mar;34:94-99.
  4. Bullimore M, Sinott LT, Jones-Jordan LA. The risk of microbial keratitis with overnight corneal reshaping lenses. Optom Vis Sci. 2013 Sep;90:937-944.
  5. Liu YM, Xie P. The Safety of Orthokeratology—A Systematic Review. Eye Contact Lens. 2016 Jan;42:35-42.
  6. Berntsen DA, Barr JT, Mitchell GL. The effect of overnight contact lens corneal reshaping on higher-order aberrations and best-corrected visual acuity. Optom Vis Sci. 2005 Jun;82:490-497.
  7. Lipson MJ, Sugar A, Musch DC. Overnight corneal reshaping versus soft disposable contact lenses: vision-related quality-of-life differences from a randomized clinical trial. Optom Vis Sci. 2005 Oct;82:886-891.
  8. Walline JJ, Lindsley K, Vedula SS, Cotter SA, Mutti DO, Twelker JD. Interventions to slow progression of myopia in children. Cochrane Database Syst Rev. 2011 Dec 7;(12):CD004916.
  9. Cho P, Cheung SW, Edwards M. The longitudinal orthokeratology research in children (LORIC) in Hong Kong: a pilot study on refractive changes and myopic control. Curr Eye Res. 2005 Jan;30:71-80.
  10. Walline JJ, Jones LA, Sinnott LT. Corneal reshaping and myopia progression. Br J Ophthalmol. 2009 Sept;93:1181-1185.
  11. Kakita T, Hiraoka T, Oshika T. Influence of overnight orthokeratology on axial elongation in childhood myopia. Invest Ophthalmol Vis Sci. 2011 Apr;52:2170-2174.
  12. Cho P, Cheung SW. Retardation of myopia in orthokeratology (ROMIO) study: a 2-year randomized clinical trial. Invest Ophthalmol Vis Sci. 2012 Oct;53:7077-7085.
  13. Hiraoka T, Kakita T, Okamoto F, Takahashi H, and Oshika T. Long-term effect of overnight orthokeratology on axial length elongation in childhood myopia: a 5-year follow-up study. Invest Ophthalmol Vis Sci. 2012 Jun 22;53:3913-3919.
  14. Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, Gutiérrez-Ortega R. Myopia control with orthokeratology contact lenses in Spain: refractive and biometric changes. Invest Ophthalmol Vis Sci. 2012 Jul 31;53:5060-5065.
  15. Charm J, Cho P. High myopia-partial reduction ortho-k: a 2-year randomized study. Optom Vis Sci. 2013 Jun;90:530-539.
  16. Si JK, Tang K, Bi HS, Guo DD, Guo JG, Wang XR. Orthokeratology for Myopia Control: A Meta-Analysis. Optom Vis Sci. 2015 Mar;92:252-257.
  17. Lipson MJ. Axial Length in Orthokeratology Patients: Large Case Series. Advances Ophthalmol Vis Sci. 2016 Nov 16. Available at . Accessed on Nov. 20, 2017.
  18. Hiraoka T, Okamoto C, Ishii Y, et al. Patient satisfaction and clinical outcomes after overnight orthokeratology. Optom Vis Sci. 2009 Jul;86:875-882.
  19. Queiros A, Villa-Collar C, Gutiérrez AR, Jorge J, González-Méijome JM. Quality of life of myopic subjects with different methods of visual correction using the NEI RQL-42 questionnaire. Eye Contact Lens. 2012 Mar;38:116-121.

(p. 46) The Scleral Lens Vault – Fitting Keratoconus
By Gregory W. DeNaeyer, OD

  1. Nau A, Nau C, Shorter E, Harthan J, Barr J, Schornack M. SCOPE Study: Indications for Scleral Lens Wear. Poster presented at the 2016 Global Specialty Lens Symposium, Las Vegas, Jan 2016.
  2. Rüfer F, Schröder A, Erb C. White-to-white corneal diameter: normal values in healthy humans obtained with the Orbscan II topography system. Cornea. 2005 Apr;24:259-261.
  3. DeNaeyer GW, Kokkinakis J, Duddek A. Specialty Lens Fitting: Learn by Example. Contact Lens Spectrum. 2017 Oct;32:32-37,45.

(p. 47) Treatment Plan – Tincture of Time Management
By William L. Miller, OD, PhD

  1. Meiri Z, Keren S, Rosenblatt A, Sarig T, Shenhav L, Varssano D. Efficacy of corneal collagen cross-linking for the treatment of keratoconus: A systematic review and meta-analysis. Cornea. 2016 Mar;35:417-428.
  2. Raiskup F, Theuring A, Pillunat LE, Spoerl E. Corneal collagen crosslinking with riboflavin and ultraviolet-A light in progressive keratoconus: ten-year results. J Cataract Refract Surg. 2015 Jan;41:41-46.
  3. Sykakis E, Karim R, Evans J, et al. Corneal collagen cross-linking for treating keratoconus. Cochrane Database Syst Rev. 2015 Mar 24;(3):CD010621.
  4. Greenstein SA, Fru KL, Bhatt J, Hersh PS. Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: Scheimpflug and biomicroscopic analysis. J. Cataract Refract Surg. 2010 Dec;36:2105-2114.
  5. Yam JC, Chan CW, Cheng AC. Corneal collagen cross-linking demarcation line depth assessed by Visante OCT after CXL for keratoconus and corneal ectasia. J Refract Surg. 2012 Jul;28:475-481.
  6. Doors M, Tahzib NG, Eggink FA, Berendschot TT, Webers CA, Nuijts RM. Use of anterior segment optical coherence tomography to study corneal changes after collagen cross-linking. Am J Ophthalmol. 2009 Dec;148:844-851.
  7. Gatzioufas Z, Balidis M, Kozeis N. Is the corneal stromal demarcation line depth a true indicator of corneal collagen crosslinking efficacy? J Cataract Refract Surg. 2016 May;42:804.
  8. Raiskup F, Hoyer A, Spoerl E. Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus. J Refract Surg. 2009 Sep;25:S824-S828.
  9. Vinciguerra P, Albé E, Frueh BE, Trazza S, Epstein D. Two-year corneal cross-linking results in patients younger than 18 years with documented progressive keratoconus. Am J of Ophthalmol. 2012 Sep;154:520-526.

(p. 48) Reader and Industry Forum – Trehalose: A Substrate with Ocular Surface Benefits
by Sarah Aumond, OD; Etty Bitton, OD, MSC; & Mile Brujic, ODÍ

  1. Garrett Q, Simmons PA, Xu S, et al. Carboxymethylcellulose binds to human corneal epithelial cells and is a modulator of corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 2007 Apr;48:1559-1567.
  2. Aragona P, Colosi P, Rania L, et al. Protective Effects of Trehalose on the Corneal Epithelial Cells. Scientific World Journal. 2014;2014:717835.
  3. Argüelles JC. Physiological roles of trehalose in bacteria and yeasts: a comparative analysis. Arch Microbiol. 2000 Oct;174:217-224.
  4. Jain NK, Roy I. Effect of trehalose on protein structure. Protein Sci. 2009 Jan;18:24-36.
  5. Elbein AD, Pan YT, Pastuszak I, Carroll D. New insights on trehalose: a multifunctional molecule. Glycobiology. 2003 Apr;13:17R-27R.
  6. Luyckx J, Baudouin C. Trehalose: an intriguing disaccharide with potential for medical application in ophthalmology. Clin Ophthalmol. 2011;5:577-581.
  7. Hill-Bator A, Misiuk-Hojlo M, Marycz K, Grzesiak J. Trehalose-Based Eye Drops Preserve Viability and Functionality of Cultured Human Corneal Epithelial Cells during Desiccation. BioMed Res Int. 2014;2014:292139.
  8. Pinto-Bonilla JC, Del Olmo-Jimeno A, Llovet-Osuna F, Hernández-Galilea E. A randomized crossover study comparing trehalose/hyaluronate eyedrops and standard treatment: patient satisfaction in the treatment of dry eye syndrome. Ther Clin Risk Manag. 2015 Apr;11:595-603.
  9. Chiambaretta F, Doan S, Labetoulle M, et al; HA-trehalose Study Group. A randomized, controlled study of the efficacy and safety of a new eyedrop formulation for moderate to severe dry eye syndrome. Eur J Ophthalmol. 2017 Jan;27:1-9.
  10. Mateo Orobia AJ, Casas Pascual P, Cristóbal Bescós JA, et al. Effects of 3% trehalose as an adjuvant treatment after LASIK. Clin Ophthalmol. 2017 Feb 16;11:347-353.
  11. Hom MM, Berdy GJ, Verachtert A, et al. Clinical evaluation of a novel lipid-containing lubricant eye drop with omega-3 oil and trehalose. Presented at ARVO 2017 Annual Meeting. 2017.