Researchers have developed an electronic contact lens capable of delivering gentle corneal stimulation to treat depressive-like behaviors in mice, according to a study recently published in Cell Reports Physical Science. The soft, wearable device combines a flexible electronic system with wireless power transfer technology to provide noninvasive electrical stimulation through the eye. Investigators said the approach leverages the connection between the cornea and the trigeminal nerve, which communicates directly with brain regions associated with mood regulation.
In the study, mice exposed to chronic stress demonstrated behavioral improvements after wearing the lens and receiving stimulation therapy. Researchers reported that treated mice showed increased exploratory behavior and reduced signs that are commonly associated with depression compared with untreated animals.
The team also incorporated artificial intelligence (AI) models to analyze behavioral and neurological changes. According to the investigators, the AI analysis frequently classified treated mice more similarly to healthy control mice than to untreated depressed mice.
Researchers noted that the contact lens produced therapeutic effects comparable to antidepressant medication in the animal model, while avoiding invasive procedures such as implanted electrodes. They added that additional studies are needed to evaluate long-term safety, optimize stimulation parameters, and determine whether the technology could eventually translate to human clinical applications.
The study authors suggested the platform could represent a future avenue for bioelectronic mental health therapies delivered through wearable ocular devices.