Objective:

To evaluate the efficacy of contact lens care products against human adenovirus type 5 (HAdV) and emphasize the critical importance of adhering to proper disinfection protocols to prevent infections.

Key Findings:

• Povidone iodine solutions achieved greater than 3-log reduction of HAdV after 4 and 6 hours of incubation, indicating strong antiviral efficacy.
• Hydrogen peroxide solutions showed a 0.52-log reduction after 6 hours, increasing to 2.18-log with extended contact time, demonstrating the importance of prolonged exposure.
• Multipurpose solutions (MPS) did not show significant reduction after 4 hours but were effective when combined with a rub-and-rinse step, highlighting the necessity of proper lens handling.

Interpretation:

Povidone iodine is significantly more effective in disinfecting contact lenses contaminated with HAdV compared to other solutions, underscoring the need for strict adherence to proper disinfection protocols in clinical practice.

Limitations:

• Limited data on the efficacy of various contact lens care products against HAdVs, which may restrict the applicability of the findings.
• Study focused only on HAdV type 5, which may not represent the efficacy against all adenovirus serotypes, potentially limiting the generalizability of the results.

Conclusion:

Proper disinfection protocols, including the use of povidone iodine and rub-and-rinse techniques, are crucial for eliminating infectious HAdVs from contact lenses.