Objective:

To evaluate the utilization, benefits, and therapeutic effects of scleral lenses in the management of ocular cicatricial pemphigoid (OCP), particularly during periods of disease quiescence.

Key Findings:

• All patients reported subjective improvement in ocular comfort after scleral lens fitting, indicating the potential for enhanced quality of life.
• Mean keratopathy grading improved from 2.1 ± 0.8 to 1.4 ± 0.7, suggesting significant clinical improvement.
• Mean visual acuity improved from 0.56 ± 0.51 to 0.34 ± 0.45 logMAR, with 46% of eyes gaining 2 or more lines of improvement, highlighting the effectiveness of scleral lenses.
• 96% of fitted eyes responded positively to treatment and continued successful scleral lens wear, demonstrating high patient satisfaction.
• Clinical signs such as fornix shortening, symblepharon, and trichiasis remained stable in patients with these findings at baseline, indicating no deterioration.

Interpretation:

Early intervention with scleral lenses is a safe and effective strategy during periods of disease quiescence in OCP management, potentially improving patient outcomes.

Limitations:

• Retrospective study design may limit the generalizability of findings and introduce biases.
• Small sample size of 20 patients may affect the robustness of the conclusions drawn.

Conclusion:

Scleral lenses should be strongly considered as an adjunctive therapy in the comprehensive management of ocular cicatricial pemphigoid, with a call for further research to establish clinical guidelines.