Clinical Report: Contact Lens Care & Compliance: Human Adenoviruses

Overview

This report highlights the resistance of human adenoviruses (HAdVs) to disinfectants and the effectiveness of various contact lens care solutions against HAdV type 5, including specific concentrations tested. Key findings indicate that povidone-iodine solutions significantly reduce viral loads, while rub-and-rinse methods enhance the efficacy of non-oxidative solutions.

Background

Human adenoviruses are a leading cause of acute viral conjunctivitis and are known for their resilience in various environments. Understanding their resistance to disinfectants is crucial for developing effective contact lens care protocols. This topic is particularly relevant given the potential for transmission in clinical settings and the need for effective disinfection methods.

Data Highlights

Key Findings

• Povidone-iodine solutions effectively reduced Ad5 to undetectable levels after 4 hours.
• Rub-and-rinse methods significantly improved the efficacy of non-oxidative solutions against Ad5.
• Hydrogen peroxide did not reduce viral load with or without rinsing before disinfection.
• All tested lens materials were equally susceptible to Ad5 contamination, with rub-and-rinse methods showing improved efficacy across materials.
• Rinsing alone with non-oxidative solutions did not significantly reduce Ad5 load.

Clinical Implications

Healthcare professionals should emphasize the importance of using povidone-iodine solutions, incorporating rub-and-rinse steps in contact lens care, and educating patients on proper hygiene practices to effectively eliminate adenoviruses.

Conclusion

The study underscores the critical role of proper contact lens care in managing the risk of adenoviral infections. Implementing recommended disinfection protocols is essential for patient safety and infection control in both clinical and home settings.

References

1. Nogueira CL, Boegel SJ, Shukla M, et al., Optom Vis Sci, 2025 -- Antiviral activity of contact lens care solutions and rub-and-rinse regimen against adenovirus
2. CDC, 2024 -- Preventing Epidemic Keratoconjunctivitis (EKC)
3. American Academy of Ophthalmology, 2024 -- Conjunctivitis Preferred Practice Pattern
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5. Contact Lens Spectrum — Contact Lens Care & Compliance: Human Adenoviruses
6. Contact Lens Spectrum — Contact Lens Care & Compliance: Human Adenoviruses
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8. Contact Lens Care & Compliance: Human Adenoviruses
9. Preventing Epidemic Keratoconjunctivitis (EKC) | Conjunctivitis (Pink Eye) | CDC
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11. Antiviral activity of contact lens care solutions and rub-and-rinse regimen against adenovirus - PMC