Objective:
To assess the antiviral efficacy of contact lens-care products against human adenovirus type 5 (Ad5) and evaluate the effectiveness of rub-and-rinse solutions in reducing viral load.
Key Findings:
- Povidone-iodine (PVP-I)-based products significantly reduced Ad5 after 4 hours.
- Rub-and-rinse solutions and 3% hydrogen peroxide required 6 hours for significant reduction of Ad5.
- Rinsing alone with non-oxidative solutions did not significantly reduce Ad5 load; however, rubbing and rinsing resulted in no detectable virus.
- PVP-I solutions effectively reduced virus load to undetectable levels.
- Hydrogen peroxide did not reduce viral load with or without rinsing.
Interpretation:
Adhering to recommended care regimens, including a rub-and-rinse step, is crucial for effectively eliminating infectious adenovirus from contact lens materials.
Limitations:
- Limited data on the effectiveness of various contact lens-care products against adenoviruses, which may affect generalizability.
- Study focused on a single adenovirus type (Ad5) and may not represent all strains, limiting applicability to other adenovirus types.
Conclusion:
Incorporating a rub-and-rinse step significantly improves the performance of non-oxidative disinfection systems against adenovirus contamination in contact lenses, emphasizing the need for adherence to recommended care regimens.
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