Clinical Scorecard: Dry Eye Dx and Tx: Preserving the Periphery
At a Glance
| Category | Detail |
|---|---|
| Condition | Limbal Stem Cell Deficiency (LSCD) |
| Key Mechanisms | Mechanical interaction of contact lenses with the cornea and reduced oxygen supply to the limbus. |
| Target Population | Patients with aphakia, high regular astigmatism, pathologic myopia, and critical observers. |
| Care Setting | Ophthalmology clinics and practices. |
Key Highlights
- Custom specialty soft lenses are beneficial for patients requiring non-standard lens powers.
- LSCD can occur due to contact lens wear, with 16.8% of cases attributed to this.
- Monitoring the limbal region under slit lamp is crucial for early detection of LSCD.
- Silicone hydrogel materials improve oxygen transmission to the cornea.
- Early LSCD treatment may involve cessation of lens wear and topical therapies.
Guideline-Based Recommendations
Diagnosis
- Clinical identification of LSCD through corneal neovascularization and fluorescein staining.
Management
- Use silicone hydrogel materials and preservative-free disinfection.
- Consider amniotic membranes, limbal transplants, and scleral lenses for advanced cases.
Monitoring & Follow-up
- Perform slit lamp exams at least annually to assess corneal health and staining.
Risks
- Higher risk of LSCD in patients with custom specialty soft lenses due to lower Dk/t values.
Patient & Prescribing Data
Patients with high prescriptions requiring custom soft lenses.
Monitor oxygen transmissibility (Dk/t) to prevent corneal edema.
Clinical Best Practices
- Remove contact lenses at every office visit for fluorescein staining tests.
- Educate patients on the importance of monitoring for symptoms of LSCD.
References
- Jeng et al, 2011
- Rossen et al, 2016
- Cheung et al, 2021
- Kim and Mian, 2017
- Holden and Mertz, 1984
- Papas, 1998
- Fonn and Bruce, 2005
- Yeung et al, 2018
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